亨廷顿舞蹈症患者外周细胞的膜流动性测量
Membrane fluidity measurements in peripheral cells from Huntington's disease patients.
作者信息
Beverstock G C, Pearson P L
出版信息
J Neurol Neurosurg Psychiatry. 1981 Aug;44(8):684-9. doi: 10.1136/jnnp.44.8.684.
Abstract
The primary gene defect of Huntington's disease is believed to involve the membrane of some peripheral cells. The membrane fluidity of skin fibroblasts, erythrocytes and leucocytes was measured by fluorescence polarisation of a lipid specific probe, 1,6 diphenyl, 1,3,5 hexatriene. No significant difference between controls and Huntington's disease patients could be demonstrated.
摘要
亨廷顿舞蹈病的主要基因缺陷被认为与某些外周细胞的细胞膜有关。通过脂质特异性探针1,6-二苯基-1,3,5-己三烯的荧光偏振来测量皮肤成纤维细胞、红细胞和白细胞的膜流动性。未发现对照组与亨廷顿舞蹈病患者之间存在显著差异。
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