Bailey L L, Petry E L, Doroshow R W, Jacobson J G, Wareham E E
J Thorac Cardiovasc Surg. 1981 Nov;82(5):779-84.
A unique concept of right ventricular outflow tract reconstruction is presented. Applications of this concept, employing a glutaraldehyde-preserved heterograft mitral valve leaflet mounted directly to the right ventricle, was studied in six immature goat models. Interval evaluation of these models demonstrated no significant outflow tract obstruction or aneurysm. Only one animal had significant pulmonary outflow regurgitation angiographically at the time of sacrifice. All heterograft valve leaflets showed a degree of calcification and/or retraction directly related to the time interval between implant and sacrifice. Encouraging early results were obtained with this method of pulmonary outflow tract reconstruction in a 2,400 gram neonate with type I truncus arteriosus.
提出了一种独特的右心室流出道重建概念。在六个未成熟山羊模型中研究了这一概念的应用，即使用直接安装在右心室上的戊二醛保存的异种移植二尖瓣叶。对这些模型的间隔评估显示没有明显的流出道梗阻或动脉瘤形成。仅一只动物在处死时血管造影显示有明显的肺流出道反流。所有异种移植瓣膜叶均显示出一定程度的钙化和/或回缩，且与植入至处死的时间间隔直接相关。在一名体重2400克的I型永存动脉干新生儿中，采用这种肺流出道重建方法获得了令人鼓舞的早期结果。
