Johnson A D, Poteete A R, Lauer G, Sauer R T, Ackers G K, Ptashne M
Nature. 1981 Nov 19;294(5838):217-23. doi: 10.1038/294217a0.
In a lysogen, most genes of phage lambda are repressed; in response to a transient induction signal, they are efficiently switched on. The switch, which consists in part of a tripartite operator to which two regulatory proteins bind, depends not only on DNA--protein interactions, but also on effects transmitted from one DNA-bound protein to another. lambda Exemplifies a strategy that facilitates efficient switching between two physiological states in response to a transient signal.
在溶原菌中，λ噬菌体的大多数基因受到抑制；响应短暂的诱导信号，它们会被有效激活。这种转换部分由一个三方操纵子组成，有两种调节蛋白与之结合，它不仅取决于DNA与蛋白质的相互作用，还取决于从一个与DNA结合的蛋白质传递到另一个蛋白质的效应。λ噬菌体体现了一种策略，即便于在响应短暂信号时在两种生理状态之间进行有效转换。
