亨廷顿舞蹈症患者亲属的血小板单胺摄取情况。

Platelet monoamine uptake in relatives of patients with Huntington's chorea.

作者信息

Ehsanullah R S, Turner P

出版信息

Postgrad Med J. 1981 Aug;57(670):479-81. doi: 10.1136/pgmj.57.670.479.

DOI:10.1136/pgmj.57.670.479

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2426140/

Abstract

Uptake of dopamine and 5-hydroxytryptamine (5-HT) by the platelets of 25 symptom-free relatives of patients with established Huntington's chorea (HC) was not significantly different from that of control subjects. Platelet uptake of 5-HT in 3 subjects with early signs of the disease showed increased Km and Vmax values. Increased platelet uptake of 5-HT in patients with established HC was confirmed in a further 3 patients. It seems that this phenomenon appears with the clinical evidence of the disease. Further investigation of the nature of the platelet uptake abnormality may cast light on pathogenic factors in HC.

摘要

25名确诊为亨廷顿舞蹈症（HC）患者的无症状亲属的血小板对多巴胺和5-羟色胺（5-HT）的摄取与对照组受试者相比无显著差异。3名有该疾病早期症状的受试者血小板对5-HT的摄取显示Km和Vmax值增加。另外3名确诊为HC的患者也证实了其血小板对5-HT的摄取增加。这种现象似乎与该疾病的临床证据同时出现。对血小板摄取异常性质的进一步研究可能会揭示HC的致病因素。

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本文引用的文献

1

L-dopa and juvenile Huntington's disease.左旋多巴与青少年型亨廷顿舞蹈症

Lancet. 1969 Nov 15;2(7629):1066. doi: 10.1016/s0140-6736(69)90662-x.

2

Plasma uptake of dopamine and 5-hydroxytryptamine and plasma-catecholamine levels in patients with Huntington's chorea.亨廷顿舞蹈病患者的多巴胺和5-羟色胺的血浆摄取及血浆儿茶酚胺水平

Lancet. 1974 Nov 9;2(7889):1115-6. doi: 10.1016/s0140-6736(74)90873-3.

3

Effects of nomifensine in vitro on uptake of 5-hydroxytryptamine and dopamine into human platelets.诺米芬辛体外对5-羟色胺和多巴胺摄入人血小板的影响。

Br J Clin Pharmacol. 1977;4Suppl 2(Suppl 2):159S-163S. doi: 10.1111/j.1365-2125.1977.tb05745.x.

4

Uptake of dopamine and 5-hydroxytryptamine by platelets from patients with Huntington's chorea.

Lancet. 1977 Jan 29;1(8005):249-50. doi: 10.1016/s0140-6736(77)91037-6.

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