诺米芬辛体外对5-羟色胺和多巴胺摄入人血小板的影响。
Effects of nomifensine in vitro on uptake of 5-hydroxytryptamine and dopamine into human platelets.
作者信息
Ehsanullah R S, Turner P
出版信息
Br J Clin Pharmacol. 1977;4Suppl 2(Suppl 2):159S-163S. doi: 10.1111/j.1365-2125.1977.tb05745.x.
Abstract
- The effect of nomifensine on the uptake of 5-hydroxytryptamine (5-HT) and dopamine (DA) into human platelet-rich plasma has been studied. 2. A significant inhibition of DA uptake was observed at nomifensine 10(-6) M. 3. 5-HT uptake was significantly inhibited only at nomifensine 10(-4) M or more. 4. These results are consistent with those from previous animal experiments and suggest that the human platelet may be used as a model for studying DA uptake as well as that of 5-HT.
摘要
- 已研究了诺米芬辛对5-羟色胺（5-HT）和多巴胺（DA）摄入富含人血小板血浆的影响。2. 在10⁻⁶M的诺米芬辛浓度下观察到DA摄取受到显著抑制。3. 仅在10⁻⁴M或更高浓度的诺米芬辛下，5-HT摄取才受到显著抑制。4. 这些结果与先前动物实验的结果一致，表明人血小板可作为研究DA摄取以及5-HT摄取的模型。
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1
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2
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Acta Physiol Scand. 1966 Jul-Aug;67(3):481-97. doi: 10.1111/j.1748-1716.1966.tb03334.x.
3
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