Schreiber V, Kölbel F, Stĕpán J, Pribyl T, Jahodová J, Kubová V
Physiol Bohemoslov. 1981;30(4):289-94.
A significant positive correlation between heart weight and adrenal weight was found in rats with myocardial hypertrophy induced by experimental hyperthyroidism or ligation of the abdominal aorta. The simultaneous administration of digitoxin partly inhibited myocardial hypertrophy after ligation of the abdominal aorta, but not after experimental hyperthyroidism. Digitoxin also inhibited adrenal hypertrophy after ligature of the abdominal aorta but, again, not after experimental hyperthyroidism. The possible existence of an endogenous cardiotropic hormone participating in the development of cardiac hypertrophy from overloading is discussed.
在实验性甲状腺功能亢进或腹主动脉结扎诱导心肌肥大的大鼠中，发现心脏重量与肾上腺重量之间存在显著正相关。同时给予洋地黄毒苷可部分抑制腹主动脉结扎后引起的心肌肥大，但对实验性甲状腺功能亢进后引起的心肌肥大无抑制作用。洋地黄毒苷还可抑制腹主动脉结扎后的肾上腺肥大，但同样对实验性甲状腺功能亢进后的肾上腺肥大无抑制作用。本文讨论了可能存在一种内源性强心激素参与因负荷过重导致心脏肥大发展的情况。
