Lorber J, Salfield S A
Arch Dis Child. 1981 Nov;56(11):822-30. doi: 10.1136/adc.56.11.822.
The results of selective treatment in 120 infants with open spina bifida, admitted between May 1971 and December 1976, were prospectively studied. Seventy-one infants had adverse criteria at birth and were not treated. They all died, more than 90% of them within 6 months of birth. Seven had meningocele. All were treated and survived without handicap. Forty-two infants with myelomeningocele were actively treated. Thirty-six survive at follow-up after 3 to 9 years. The quality of survival is much better than when selection was not used but 8 children have moderate or severe handicaps. The parents were fully informed and consulted at every decision-making step; they fully supported the principle of selection and the action taken on behalf of their own child.
对1971年5月至1976年12月期间收治的120例开放性脊柱裂婴儿进行选择性治疗的结果进行了前瞻性研究。71例婴儿出生时具有不良标准，未接受治疗。他们全部死亡，其中90%以上在出生后6个月内死亡。7例患有脊膜膨出。全部接受治疗且存活，无残疾。42例脊髓脊膜膨出婴儿接受了积极治疗。36例在3至9年的随访后存活。生存质量比未采用选择治疗时要好得多，但仍有8名儿童有中度或重度残疾。在每一个决策步骤都充分告知并咨询了家长；他们完全支持选择原则以及为自己孩子采取的行动。
