与H-2D紧密连锁的另一个H-2区域的免疫化学证据。
Immunochemical evidence for an additional H-2 region closely linked to H-2D.
作者信息
Hansen T H, Cullen S E, Sachs D H
出版信息
J Exp Med. 1977 Feb 1;145(2):438-42. doi: 10.1084/jem.145.2.438.
Abstract
Anti-H-2 reagents have been tested on solubilized spleen cell preparations in combinations expected to be specific for D region products. Two different types of molecules were detected. One showed the expected reactivity with both antisera to private and antisera to public specificities. However, an additional molecule was detected which reacted only with antisera to public specificities. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis migration patterns indicated that both products have a similar molecular size of approximately 45,000 daltons. The data therefore present chemical evidence for the existence of a third H-2-associated gene product of 45,000 mol wt in addition to the classical H-2K and H-2D antigens.
摘要
抗H-2试剂已在溶解的脾细胞制剂上进行了测试，这些组合预期对D区产物具有特异性。检测到两种不同类型的分子。一种对针对私有特异性的抗血清和针对公共特异性的抗血清均显示出预期的反应性。然而，还检测到另一种分子，它仅与针对公共特异性的抗血清发生反应。十二烷基硫酸钠-聚丙烯酰胺凝胶电泳迁移模式表明，这两种产物的分子大小相似，约为45,000道尔顿。因此，这些数据提供了化学证据，证明除了经典的H-2K和H-2D抗原外，还存在一种分子量为45,000的第三种H-2相关基因产物。
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