Paponov V D, Gromov P S, Krasnov P A, Spitkovskiĭ D M
Vopr Med Khim. 1981 Sep-Oct;27(5):666-8.
Using polyacrylamide gel electrophoresis an additional protein band was found in the leukocyte preparation obtained from patients with Down syndrome as compared with the cells of healthy donors. Impairments in gene expression, due to alteration in the ratio between content of histone genes and of nuclear DNA, were apparently responsible for qualitative alterations in the cell protein composition under conditions of aneuploidy as well as for the quantitative alterations, deviating from the principle of "gene dosage".
与健康供体的细胞相比，使用聚丙烯酰胺凝胶电泳发现在唐氏综合征患者的白细胞制剂中有一条额外的蛋白带。由于组蛋白基因含量与核DNA含量比例的改变导致的基因表达受损，显然是造成非整倍体情况下细胞蛋白质组成定性改变以及偏离“基因剂量”原则的定量改变的原因。
