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异丙托溴铵口服治疗窦性心动过缓患者后的心率行为和血流动力学(作者译)

[Heart rate behaviour and hemodynamics after oral therapy with ipratropium bromide in patients with sinus bradycardia (author's transl)].

作者信息

Kikis D, Esser H, Heinrich K

出版信息

Arzneimittelforschung. 1981;31(10):1751-4.

PMID:6459098
Abstract

Haemodynamic parameters were measured in 11 patients with sinus bradycardia before and 2.5, 4, 6 and 10 h following p.o. administration of 10 mg 8-isopropyl-3 alpha-DL-tropoyloxy-1 alpha H, 5 alpha H-tropanium hydroxide (ipratropium-bromide, Sch 1000). 2.5 h after Sch 1000 there was a significant rise in heart rate (p less than 0.001) which was still significantly elevated above control values 10 h following ipratropiumbromide ingestion (57.5 +/- 13.2 beats/min; p less than 0.001). Cardiac index was increased following ipratropiumbromide treatment and this was accompanied by a decrease in stroke volume.

摘要

在11例窦性心动过缓患者口服10毫克8-异丙基-3α-DL-托品酰氧基-1αH,5αH-托烷氢氧化铵(异丙托溴铵,Sch 1000)之前以及服药后2.5、4、6和10小时测量血流动力学参数。服用Sch 1000后2.5小时心率显著升高(p<0.001),在摄入异丙托溴铵10小时后仍显著高于对照值(57.5±13.2次/分钟;p<0.001)。异丙托溴铵治疗后心脏指数增加,同时每搏量减少。

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