Kikis D, Esser H, Heinrich K
Arzneimittelforschung. 1981;31(10):1751-4.
Haemodynamic parameters were measured in 11 patients with sinus bradycardia before and 2.5, 4, 6 and 10 h following p.o. administration of 10 mg 8-isopropyl-3 alpha-DL-tropoyloxy-1 alpha H, 5 alpha H-tropanium hydroxide (ipratropium-bromide, Sch 1000). 2.5 h after Sch 1000 there was a significant rise in heart rate (p less than 0.001) which was still significantly elevated above control values 10 h following ipratropiumbromide ingestion (57.5 +/- 13.2 beats/min; p less than 0.001). Cardiac index was increased following ipratropiumbromide treatment and this was accompanied by a decrease in stroke volume.
在11例窦性心动过缓患者口服10毫克8-异丙基-3α-DL-托品酰氧基-1αH，5αH-托烷氢氧化铵（异丙托溴铵，Sch 1000）之前以及服药后2.5、4、6和10小时测量血流动力学参数。服用Sch 1000后2.5小时心率显著升高（p<0.001），在摄入异丙托溴铵10小时后仍显著高于对照值（57.5±13.2次/分钟；p<0.001）。异丙托溴铵治疗后心脏指数增加，同时每搏量减少。
