Trieb G, Mertens H M, Bistreanu I, Mannebach H, Gleichmann U
Z Kardiol. 1979 Oct;68(10):700-4.
Electrophysiological effects of the atropin ester Ipatropiumbromide (SCH 1000) were investigated in 15 patients by His electrocardiography and high frequency atrial stimulation. Heart rate increased by 50% of base line heart rate, PA- and AH-intervals and sinus node recovery time decreased, the HF-interval remained unchanged. Physiological av-block by atrial stimulation occurred at significant higher stimulation frequencies with SCH 1000 than without medication. Additional 15 patients were treated for a longer follow-up period. Increase of resting heart rate averaged 15%. Equivocal effects on heart rate were found with exercise after SCH 1000. Non-cardiac side effects were found in 5 patients.
通过希氏束心电图和高频心房刺激，对15例患者研究了阿托品酯异丙托溴铵（SCH 1000）的电生理效应。心率增加至基线心率的50%，PA间期和AH间期以及窦房结恢复时间缩短，HF间期保持不变。与未用药时相比，使用SCH 1000时，通过心房刺激产生生理性房室传导阻滞所需的刺激频率显著更高。另外15例患者接受了更长时间的随访治疗。静息心率平均增加15%。使用SCH 1000后运动时，对心率的影响不明确。5例患者出现非心脏副作用。
