Sugishita Y, Kakihana M, Murao S
Am J Physiol. 1978 May;234(5):H625-8. doi: 10.1152/ajpheart.1978.234.5.H625.
To gain more knowledge about the factors involved in reactive hyperemia in the coronary vessels, we performed comparative studies on the reactive hyperemia occurring after coronary occlusion and after coronary perfusion with nonoxygenated Tyrode solution. The peak coronary reactive hyperemic flow following 3 min of coronary perfusion with nonoxygenated Tyrode solution increased to only 142 +/- 16% of the control in contrast to 455 +/- 75% following 3 min of coronary occlusion alone. Myocardial oxygen uptake during reactive hyperemia was also much smaller after perfusion with Tyrode solution. First, the evidence suggests that the decreased reactive hyperemia after coronary perfusion with the nonoxygenated Tyrode solution is due to "washout" of the vasodilatory metabolites from the myocardium. Second, it suggests that there is a smaller "energy debt" during perfusion with Tyrode solution, so that deterioration of myocardial function due to oxygen deficiency is less severe than in coronary occlusion alone.
为了更深入了解冠状动脉反应性充血所涉及的因素，我们对冠状动脉闭塞后以及用无氧台氏液进行冠状动脉灌注后出现的反应性充血进行了对比研究。用无氧台氏液进行3分钟冠状动脉灌注后，冠状动脉反应性充血峰值流量仅增至对照值的142±16%，而单独冠状动脉闭塞3分钟后该值为455±75%。在用台氏液灌注后反应性充血期间的心肌摄氧量也小得多。首先，有证据表明，用无氧台氏液进行冠状动脉灌注后反应性充血减少是由于心肌中血管舒张代谢产物被“冲洗掉”。其次，这表明在用台氏液灌注期间“能量亏欠”较小，因此与单独冠状动脉闭塞相比，因缺氧导致的心肌功能恶化没那么严重。
