Ward D G, Adair J R, Schramm L P, Gann D S
Am J Physiol. 1978 May;234(5):R223-8. doi: 10.1152/ajpregu.1978.234.5.R223.
The role of the parabrachial region of the dorsal rostral pons (PB) in mediating control of renal blood flow and of systemic arterial blood pressure was investigated in nine cats anesthetized with chloralose-urethan. Electrical stimulation through electrodes placed stereotaxically in lateral and medial positions in the hypothalamus (LH and MH) in PB and in ventrolateral reticular formation (VLRF) of each cat elicited pronounced systemic arterial pressor responses and renal vasoconstrictions. Stimulation parameters were adjusted so that renal flow responses elicited from each site were equal. Following a unilateral lesion in the PB, responses of renal vasoconstriction induced by hypothalamic stimulation were attenuated, but responses of arterial pressure were not altered. Stimulation of the VLRF, posterior to the lesion, consistently produced undiminished systemic pressor responses and renal vasoconstriction throughout the durations of the experiments excluding decay of renal vascular responsiveness. Thus, the data suggest that pathways mediating renal vasoconstriction in response to hypothalamic stimulation was discrete and pass through the parabrachial region, whereas pathways mediating systemic vasoconstriction in response to hypothalamic stimulation are distinct or less compact.
在9只用氯醛糖-乌拉坦麻醉的猫中，研究了脑桥背侧吻端臂旁区（PB）在介导肾血流量和全身动脉血压控制中的作用。通过立体定位放置在每只猫下丘脑外侧和内侧部位（LH和MH）、PB以及腹外侧网状结构（VLRF）的电极进行电刺激，引发了明显的全身动脉升压反应和肾血管收缩。调整刺激参数，使从每个部位引发的肾血流反应相等。在PB进行单侧损伤后，下丘脑刺激诱导的肾血管收缩反应减弱，但动脉血压反应未改变。在损伤后侧刺激VLRF，在排除肾血管反应性衰减的整个实验过程中，始终产生未减弱的全身升压反应和肾血管收缩。因此，数据表明，介导下丘脑刺激引起的肾血管收缩的通路是离散的且经过臂旁区，而介导下丘脑刺激引起的全身血管收缩的通路是不同的或不太紧密的。
