Kutseva L S, Bazdyreva N M, Ivanova L B
Prikl Biokhim Mikrobiol. 1981 Nov-Dec;17(6):832-6.
The ability of five bacterial strains, i.e., Brevibacterium ammoniagenes ATCC 6872, Brevibacterium flavum ATCC 14067, Brevibacterium 22, Corynebacterium ATCC 21084, Micrococcus glutamicus ATCC 13032, to utilize exogenous precursors (nicotinamide and adenine or ATP) was investigated during NAD synthesis under fermentation conditions and during incubation of acetone-dried cells. It was found that dry cells of Brevibacterium three strains were most active. However, under fermentation conditions Br. flavum ATCC 14067 and Brevibacterium 22 accumulated NAD in the amounts 3J4 times lower than the well-known producer Br. ammoniagenes ATCC 6872. One of the possible factors responsible for the low yield of NAD by Brevibacterium 22 under fermentation conditions can be the reduced ribose synthesis.
研究了五种细菌菌株，即产氨短杆菌ATCC 6872、黄色短杆菌ATCC 14067、短杆菌22、棒状杆菌ATCC 21084、谷氨酸微球菌ATCC 13032，在发酵条件下NAD合成过程中以及丙酮干燥细胞孵育期间利用外源前体（烟酰胺和腺嘌呤或ATP）的能力。发现三种短杆菌菌株的干燥细胞活性最高。然而，在发酵条件下，黄色短杆菌ATCC 14067和短杆菌22积累的NAD量比著名的生产菌株产氨短杆菌ATCC 6872低3至4倍。发酵条件下短杆菌22的NAD产量低的一个可能因素可能是核糖合成减少。
