Lehucher-Ceyrac D, Weber-Buisset M J, Saurat J H
Ann Dermatol Venereol. 1981;108(11):861-8.
37 women have received during a total of 429 cycles (mean 12 cycles/patients) an association containing cyproterone acetate 2 mg and ethinyl estradiol 0.05 mg. A marked improvement in the clinical symptoms (acne 35 cases) has been observed. The sequential determination of the sebum excretion rate has been made in the same time (150 measurements) and revealed an important, early and durable decrease in the sebum excretion rate. The respective role of the CA and EE has been analysed in a second trial. It seems that the antiandrogen might play a role in the clinical improvement and in the reduction of the sebaceous flow.
37名女性在总共429个周期（平均每位患者12个周期）中接受了含有2毫克醋酸环丙孕酮和0.05毫克炔雌醇的联合用药。观察到临床症状（35例痤疮）有显著改善。同时对皮脂分泌率进行了连续测定（150次测量），结果显示皮脂分泌率出现了重要、早期且持久的下降。在第二项试验中分析了醋酸环丙孕酮（CA）和炔雌醇（EE）各自的作用。似乎抗雄激素可能在临床改善和皮脂分泌减少中发挥作用。
