Greenwood R, Brummitt L, Burke B, Cunliffe W J
Br Med J (Clin Res Ed). 1985 Nov 2;291(6504):1231-5. doi: 10.1136/bmj.291.6504.1231.
Since the recent introduction of a drug regimen containing 2 mg of the antiandrogen cyproterone acetate and 50 micrograms ethinyl-oestradiol (Diane; oestrogen-cyproterone acetate) several uncontrolled reports have extolled the benefits of this drug. Double blind studies, however, are lacking. Sixty two patients with moderate or moderately severe acne were therefore included in a double blind trial of treatment for six months comparing tetracycline alone, oestrogen-cyproterone acetate alone, and a combination of these agents. Sebum excretion rates and bacterial counts were measured before, during, and after treatment, at the same time as a clinical assessment was made. At six months the acne (as assessed by overall grade) had improved by 68% in the antibiotic treated group and by 74% in the oestrogen-cyproterone treated group. The group given a combination of both agents improved by 82%, which was significantly better (p less than 0.025) than the improvement in the tetracycline treated patients. No significant difference was found between the groups given oestrogen-cyproterone alone and the combined treatment. The sebum excretion rate was suppressed by 25% in the patients in both groups receiving oestrogen-cyproterone but not in the group given antibiotics alone. Oestrogen-cyproterone acetate is as effective as antibiotics in treating acne in women, and adding antibiotics offers no advantage over using oestrogen-cyproterone on its own, although in this study the combination was more effective than tetracycline alone at six months.
自从最近引入了一种含有2毫克抗雄激素醋酸环丙孕酮和50微克炔雌醇的药物疗法（达英；雌激素 - 醋酸环丙孕酮）以来，已有多篇非对照报告称赞了这种药物的益处。然而，缺乏双盲研究。因此，62名中度或中度重度痤疮患者被纳入一项为期六个月的双盲治疗试验，比较单独使用四环素、单独使用雌激素 - 醋酸环丙孕酮以及这两种药物的组合。在治疗前、治疗期间和治疗后测量皮脂分泌率和细菌计数，同时进行临床评估。六个月时，抗生素治疗组的痤疮（根据总体分级评估）改善了68%，雌激素 - 醋酸环丙孕酮治疗组改善了74%。两种药物联合使用的组改善了82%，这明显优于（p小于0.025）四环素治疗患者的改善情况。单独使用雌激素 - 醋酸环丙孕酮的组与联合治疗组之间未发现显著差异。接受雌激素 - 醋酸环丙孕酮的两组患者的皮脂分泌率均降低了25%，但单独使用抗生素的组未降低。醋酸环丙孕酮在治疗女性痤疮方面与抗生素一样有效，并且添加抗生素相对于单独使用雌激素 - 醋酸环丙孕酮没有优势，尽管在本研究中，联合治疗在六个月时比单独使用四环素更有效。
