Silfverstolpe G, Samsioe G, Svanborg A, Gustafson A
Gynecol Obstet Invest. 1982;13(2):117-26. doi: 10.1159/000299492.
Norethisterone acetate (NET), levonorgestrel (NORG) and medroxyprogesterone acetate (MPA) were administered to oophorectomized women to evaluate the effects on individual serum phospholipids as well as serum lecithin and cholesterol ester fatty acid composition. Blood samples were drawn after a 3-week period without hormonal replacement therapy and after 3 weeks on each progestogen. NORG reduced cepahlin and lecithin with a concomitant increase in lysolecithin. This shift in individual phospholipids has previously been induced by exogenous androgens. The 17C-alkylated synthetic progestogens NET and NORG but not the non-alkylated MPA caused a redistribution among the 1-position fatty acids of serum lecithin with an increase in palmitic concomitant with a decrease in stearic acid. These findings indicate differences between 19-nortestosterone derivatives and 17-hydroxyprogesterone derivatives in effect on individual serum phospholipids and in influence on liver lecithin synthesis as judged from serum lecithin fatty acid composition.
将醋酸炔诺酮（NET）、左炔诺孕酮（NORG）和醋酸甲羟孕酮（MPA）给予卵巢切除的女性，以评估其对个体血清磷脂以及血清卵磷脂和胆固醇酯脂肪酸组成的影响。在无激素替代治疗的3周后以及每种孕激素治疗3周后采集血样。NORG降低了脑磷脂和卵磷脂，同时溶血卵磷脂增加。个体磷脂的这种变化先前已由外源性雄激素诱导产生。17α-烷基化合成孕激素NET和NORG而非非烷基化的MPA导致血清卵磷脂1位脂肪酸重新分布，棕榈酸增加，硬脂酸减少。这些发现表明，从血清卵磷脂脂肪酸组成判断，19-去甲睾酮衍生物和17-羟孕酮衍生物在对个体血清磷脂的影响以及对肝脏卵磷脂合成的影响方面存在差异。
