Greer W L, Wellman A M
Can J Biochem. 1981 Nov-Dec;59(11-12):933-6. doi: 10.1139/o81-131.
Guanosine competitively inhibits the uptake of adenine and hypoxanthine by the general purine-base permease in conidia of Neurospora crassa. There is no reciprocal effect of adenine or hypoxanthine on guanosine uptake so it is suggested that guanosine can bind to the general purine-base permease to cause this inhibition but is not transported through this system. It is known that guanosine is transported by two separate nucleoside transport sites. Guanosine also noncompetitively inhibits the specific adenine uptake system of germinating conidia.
鸟苷竞争性抑制粗糙脉孢菌分生孢子中通用嘌呤碱通透酶对腺嘌呤和次黄嘌呤的摄取。腺嘌呤或次黄嘌呤对鸟苷摄取没有相反作用，因此表明鸟苷可与通用嘌呤碱通透酶结合导致这种抑制，但不通过该系统转运。已知鸟苷由两个独立的核苷转运位点转运。鸟苷还非竞争性抑制萌发分生孢子的特异性腺嘌呤摄取系统。
