Experimental study of the effect on rabbits of the injectable contraceptive medroxyprogesterone acetate, cholesterol feeding and drug-atherogenic diet combination.

Medroxyprogesterone acetate was given alone or in combination with a cholesterolll-rich diet. Total serum cholesterol levels in treated rabbits was significantly different from those of the control on most occasions during the experiment, and in the controls it remained essentially the same throughout the experimental period. There was a relationship between lesions induced and the raised serum cholesterol, but there was no regression of the appearance of fibrous plaques after discontinuation of the cholestero supplement.