[儿童有机酸研究中的方法学]
[Methodology in the study of organic acids in children].
作者信息
Lefebvre E, Vidailhet M, Rousselot J M, Morali A
出版信息
C R Seances Soc Biol Fil. 1982;176(1):30-8.
PMID:6461392
Abstract
A method is described for the extraction of urinary organic acids in children, their conversion to TMS and oxime TMS derivatives and their separation by gas liquid chromatography on a packed column of 10% OV 101. The compounds are identified by mass spectrometry. Profiles of urinary organic acids in normal neonates and in several metabolic disorders are presented.
摘要
本文描述了一种用于提取儿童尿中有机酸的方法，将其转化为三甲基硅烷（TMS）和肟基三甲基硅烷衍生物，并通过在填充有10% OV 101的柱上进行气液色谱分离。通过质谱对这些化合物进行鉴定。文中给出了正常新生儿和几种代谢紊乱患儿尿中有机酸的图谱。
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