单相抑郁症亚型中的促甲状腺激素释放激素刺激试验。

The TRH stimulation test in subtypes of unipolar depression.

作者信息

Targum S D, Byrnes S M, Sullivan A C

出版信息

J Affect Disord. 1982 Mar;4(1):29-34. doi: 10.1016/0165-0327(82)90016-7.

Abstract

The thyrotropin releasing hormone (TRH) stimulation test was administered to 54 primary unipolar endogenously depressed and 19 non-depressed hospitalized inpatients. Blunted TSH responses to TRH infusion (delta max TSH less than 7 microunits/ml) were revealed in 18 depressed and no non-depressed patients (P less than 0.01). Augmented TSH responses (delta max TSH greater than 23 microunits/ml) were noted in 8 depressed and no non-depressed patients (P = n.s.). The TRH stimulation test did not distinguish between subtypes of unipolar depression using the familial subtyping criteria of Winokur. These findings are discussed in light of previously reported dexamethasone suppression test subtype distinctions.

摘要

对54例原发性单相内源性抑郁症住院患者和19例非抑郁症住院患者进行了促甲状腺激素释放激素（TRH）刺激试验。18例抑郁症患者出现对TRH输注的促甲状腺激素（TSH）反应迟钝（最大TSH变化量小于7微单位/毫升），而非抑郁症患者中无此现象（P<0.01）。8例抑郁症患者出现TSH反应增强（最大TSH变化量大于23微单位/毫升），非抑郁症患者中无此现象（P无统计学意义）。使用Winokur的家族分型标准，TRH刺激试验无法区分单相抑郁症的亚型。根据先前报道的地塞米松抑制试验亚型差异对这些发现进行了讨论。