Targum S D, Byrnes S M, Sullivan A C
J Affect Disord. 1982 Mar;4(1):21-7. doi: 10.1016/0165-0327(82)90015-5.
The dexamethasone suppression test (DST) was administered to 54 primary unipolar depressed patients and 19 non-depressed hospitalized inpatients. Abnormal DST were found in 23 depressed patients (43%) in contrast to 2 (11%) non-depressed patients (P less than 0.05). Within the endogenously depressed group, 69% of patients categorized as familial pure depressive disease (FPDD) in contrast to 13% of depressive spectrum disease (DSD) patients had abnormal DST results (P less than 0.02). The DSD group had significantly fewer abnormal DST results than all other subtypes of unipolar depression (P less than 0.05). The distinction revealed between DSD patients and other endogenously depressed patients may be due to biological factors or due to the heterogeneous nature of the DSD subtype group.
对54例原发性单相抑郁症患者和19例非抑郁住院患者进行了地塞米松抑制试验（DST）。23例抑郁症患者（43%）DST结果异常，相比之下，2例非抑郁患者（11%）DST结果异常（P<0.05）。在内源性抑郁症组中，69%归类为家族性单纯抑郁症（FPDD）的患者DST结果异常，相比之下，抑郁谱系障碍（DSD）患者中这一比例为13%（P<0.02）。DSD组DST结果异常的患者明显少于单相抑郁症的所有其他亚型（P<0.05）。DSD患者与其他内源性抑郁症患者之间的差异可能是由于生物学因素或DSD亚型组的异质性。
