Hough L B, Su K L, Goldschmidt R C, Khandelwal J K, Newton M V, Glick S D
Neuropharmacology. 1984 Jun;23(6):705-9. doi: 10.1016/0028-3908(84)90169-2.
A role for brain histamine in the acute action of morphine was studied in mice. In contrast to earlier reports, whole brain histamine levels were not changed 30 min after morphine (1-56 mg/kg). Levels of the brain histamine metabolite, tele-methylhistamine were also unchanged. Morphine (1.8-10 mg/kg) caused a dose-dependent antinociceptive response that was unaffected by histamine H1-antagonists (i.p.), H2-antagonists (i.p. or i.vent.), or metoprine (i.p.), an inhibitor of histamine metabolism. alpha-Fluoromethylhistidine, the inhibitor of brain histamine synthesis, unexpectedly potentiated the response to low doses of morphine. These results find no evidence for a role of brain histamine in opiate analgesia.
在小鼠中研究了脑内组胺在吗啡急性作用中的作用。与早期报告相反，吗啡（1 - 56毫克/千克）给药30分钟后，全脑组胺水平未发生变化。脑内组胺代谢产物3-甲基组胺的水平也未改变。吗啡（1.8 - 10毫克/千克）引起剂量依赖性的抗伤害感受反应，该反应不受组胺H1拮抗剂（腹腔注射）、H2拮抗剂（腹腔注射或脑室内注射）或组胺代谢抑制剂美托普利（腹腔注射）的影响。脑内组胺合成抑制剂α-氟甲基组氨酸意外地增强了对低剂量吗啡的反应。这些结果没有发现脑内组胺在阿片类镇痛中起作用的证据。
