Nishibori M, Oishi R, Itoh Y, Saeki K
J Neurochem. 1985 Sep;45(3):719-24. doi: 10.1111/j.1471-4159.1985.tb04051.x.
The effect of the acute morphine treatment on histamine (HA) pools in the brain and the spinal cord was examined in mice. Morphine (1-50 mg/kg, s.c.) administered alone caused no significant change in the steady-state levels of HA and its major metabolite, tele-methylhistamine (t-MH), in the brain. However, depending on the doses tested, morphine significantly enhanced the pargyline (65 mg/kg, i.p.)-induced accumulation of t-MH and this effect was antagonized by naloxone. A specific inhibitor of histidine decarboxylase, alpha-fluoromethylhistidine (alpha-FMH) (50 mg/kg, i.p.), decreased the brain HA level in consequence of the almost complete depletion of the HA pool with a rapid turnover. Morphine further decreased the brain HA level in alpha-FMH-pretreated mice. Morphine administered alone significantly reduced the HA level in the spinal cord, an area where the turnover of HA is very slow. These results suggest that the acute morphine treatment increases the turnover of neuronal HA via opioid receptors, and this opiate also releases HA from a slowly turning over pool(s).
在小鼠中研究了急性吗啡处理对脑和脊髓中组胺（HA）池的影响。单独给予吗啡（1 - 50 mg/kg，皮下注射）对脑中HA及其主要代谢产物，即甲基组胺（t - MH）的稳态水平没有显著影响。然而，根据所测试的剂量，吗啡显著增强了帕吉林（65 mg/kg，腹腔注射）诱导的t - MH积累，且这种作用被纳洛酮拮抗。组氨酸脱羧酶的特异性抑制剂，α-氟甲基组氨酸（α - FMH）（50 mg/kg，腹腔注射），由于HA池几乎完全耗尽且周转迅速，导致脑HA水平降低。吗啡进一步降低了经α - FMH预处理小鼠的脑HA水平。单独给予吗啡显著降低了脊髓中的HA水平，在脊髓中HA的周转非常缓慢。这些结果表明，急性吗啡处理通过阿片受体增加了神经元HA的周转，并且这种阿片类药物还从周转缓慢的池中释放HA。
