Coderre T J, Abbott F V, Melzack R
Neurosci Lett. 1984 Jun 15;47(2):113-8. doi: 10.1016/0304-3940(84)90415-4.
Cutaneous sensory and vascular function was examined following application of capsaicin to the sciatic nerve and systemic injection of guanethidine. Together the two drugs produced a reduction in sensitivity to heat-pain, inflammatory pain (formalin test), tactile stimulation and skin temperature of the foot that exceeded the effects of either drug alone. The inflammation produced by an injection of formalin to the plantar surface of the hind paw was reduced equally by capsaicin or capsaicin + guanethidine. Cold sensitivity and inflammation produced by yeast injection were unaffected by all treatments. The data imply a peripheral interaction between peptidergic and noradrenergic systems with significant functional implications that may be important in the pathology of familial dysautonomia.
在将辣椒素应用于坐骨神经并全身注射胍乙啶后，对皮肤感觉和血管功能进行了检查。这两种药物共同作用时，对热痛、炎性疼痛（福尔马林试验）、触觉刺激和足部皮肤温度的敏感性降低程度超过了单独使用任何一种药物的效果。向大鼠后爪足底表面注射福尔马林所产生的炎症，辣椒素或辣椒素 + 胍乙啶均可同等程度地减轻。注射酵母所产生的冷敏感性和炎症不受所有治疗的影响。这些数据表明肽能系统和去甲肾上腺素能系统之间存在外周相互作用，具有重要的功能意义，这可能在家族性自主神经功能异常的病理学中起重要作用。
