Martin R J, Ramsay T, Hausman G J
Pediatr Ann. 1984 Jun;13(6):448-53.
Our understanding of adipocyte development has advanced rapidly over the last ten years. New developments in adipocyte methodologies have allowed rapid progress. Both histochemical and ultrastructural evaluation of normal and abnormal adipocyte development has increased our understanding of the complexities of cell proliferation and differentiation and the identification of the adipocyte precursor. Adipose tissue transplant studies have shown that some forms of genetic obesity do not involve inherent differences in the adipocyte but do involve some serum factor which predisposes an individual to adipocyte hypertrophy. Cell culture procedures have been developed recently which will allow us to answer more difficult questions concerning adipocyte proliferation and its regulation. The ultimate goals of understanding the complexities of adipocyte development should lead to some practical approaches for the prevention and control of childhood obesity.
在过去十年里，我们对脂肪细胞发育的理解取得了迅速进展。脂肪细胞研究方法的新进展推动了快速进步。对正常和异常脂肪细胞发育的组织化学和超微结构评估，增进了我们对细胞增殖和分化复杂性以及脂肪细胞前体识别的理解。脂肪组织移植研究表明，某些形式的遗传性肥胖并不涉及脂肪细胞的内在差异，而是涉及某种使个体易患脂肪细胞肥大的血清因子。最近已开发出细胞培养程序，这将使我们能够回答有关脂肪细胞增殖及其调控的更难题。理解脂肪细胞发育复杂性的最终目标应能带来一些预防和控制儿童肥胖的实用方法。
