Lubetzki J, Roussel C, Mosse A, Duprey J, Warnet A, Bargy D
Pathol Biol (Paris). 1980 Jan;28(1):17-24.
In spite of the methodological reserves that the measure of adipocyte volume and the calculation of the number of adipocytes evoke, it appeared interesting to us to study these parameters in a group of 102 obese subjects in reference to some clinical and biological criteria. The following conclusions come out of this study. The greater the obesity, the greater the adipocyte volume. There is a positive correlation between the importance of obesity and cellularity of the adipose tissue. However, this correlation is no longer found for the most obese patients, in whom adipocyte hypertrophy intervenes but no longer the multiplication of the fat cells. The onset of obesity at adolescence pairs with a number of adipocytes higher than in the other chronological forms: obesity appearing at adolescence would be thus more frequently hyperplastic. This characteristic is not discovered in the cases of obesity appearing in infancy. No relation was found between the existence of impaired glucose tolerance and mean adipocyte diameter and/or the number of adipocytes. It has been the same for the cases of hyperlipidemia.
尽管测量脂肪细胞体积和计算脂肪细胞数量的方法存在局限性，但我们认为针对102名肥胖受试者，参照一些临床和生物学标准来研究这些参数很有意思。本研究得出了以下结论。肥胖程度越高，脂肪细胞体积越大。肥胖程度与脂肪组织细胞数量之间存在正相关。然而，在最肥胖的患者中不再发现这种相关性，这些患者中脂肪细胞肥大起作用，但脂肪细胞不再增殖。青春期开始肥胖的患者其脂肪细胞数量高于其他年龄段：因此青春期出现的肥胖更常为增生性肥胖。在婴儿期出现肥胖的病例中未发现这一特征。糖耐量受损的存在与平均脂肪细胞直径和/或脂肪细胞数量之间未发现关联。高脂血症病例也是如此。
