Czeizel A, Szentesi I, Molnár G
Acta Med Hung. 1984;41(2-3):77-92.
Individuals who poison themselves in a suicide attempt with extremely large doses of chemicals may comprise a population that is useful for the study of the possible mutagenicity of drugs and other compounds. After the demonstration of the demographic data of completed and attempted suicide cases, the methodology of short-term somatic and long-term germinal mutagenesis systems are described. Finally the advantages and disadvantages of this human experimental epidemiological model are discussed, pointing out the practical and theoretical importance of the approach.
那些使用超大剂量化学物质进行自杀性中毒的个体，可能构成一个对研究药物和其他化合物潜在致突变性有用的人群。在展示了已完成和未遂自杀案例的人口统计学数据后，描述了短期体细胞和长期生殖细胞致突变系统的方法。最后讨论了这种人类实验性流行病学模型的优缺点，指出了该方法在实践和理论上的重要性。
