Czeizel A E
Department of Human Genetics and Teratology, National Institute of Hygiene-WHO Collaborating Centre for the Community Control of Hereditary Diseases, Budapest, Hungary.
Mutat Res. 1994 Oct-Dec;313(2-3):175-81. doi: 10.1016/0165-1161(94)90047-7.
Persons who attempt suicide by taking high doses of chemicals but survive may represent an appropriate human model of mutagenesis epidemiology for the study of somatic and germinal mutagenicity of drugs, pesticides and other chemicals. The most important results of systematic studies in self-poisoning individuals over the last 20 years are summarized. Trichlorfon and diazepam caused a higher rate of aneuploidy in peripheral lymphocytes. The frequency of chromatid aberrations was lower in self-poisoned pregnant women than in self-poisoned non-pregnant women and these findings suggest a possible protective effect of pregnancy. Intrauterine growth retardation was found in children born after self-poisoning.
通过大量服用化学品自杀但幸存下来的人，可能是研究药物、农药及其他化学品的体细胞和生殖细胞致突变性的合适的人类诱变流行病学模型。本文总结了过去20年对自我中毒个体进行系统研究的最重要结果。敌百虫和地西泮在外周淋巴细胞中导致更高的非整倍体率。自我中毒的孕妇中染色单体畸变的频率低于自我中毒的非孕妇，这些发现表明怀孕可能具有保护作用。在自我中毒后出生的儿童中发现了宫内生长迟缓。
