Pharmacokinetics of paracetamol in patients with gastric and duodenal ulcers.

Pharmacokinetics of orally applied single dose of paracetamol was studied in patients with gastric ulcer and duodenal ulcer. The course of changes in paracetamol concentration was described using a two-compartment open model for extravascular administration; the calculations were carried out using an Odra 1300 computer. The changes in pharmacokinetics of paracetamol in the patients with gastric and duodenal ulcer was altered: the absorption was increased particularly in patients with duodenal ulcerosis and delayed in patients with both gastric and duodenal ulcers.