Stacey N E
Pharmacol Biochem Behav. 1984 Jun;20(6):887-91. doi: 10.1016/0091-3057(84)90013-3.
Previous studies have indicated that female spawning behavior in goldfish is stimulated by prostaglandin (PG) synthesized in the reproductive tract shortly after ovulation and acting within the brain. In this study, clonidine inhibited PG-induced spawning behavior of nonovulated female goldfish in a dose-dependent manner and also inhibited spawning of ovulated goldfish. In male goldfish, clonidine also inhibited PG-induced female spawning behavior but did not affect male spawning behavior. The results provide further support for a role of endogenous PG in female spawning behavior of goldfish and are consistent with the findings [15] that clonidine antagonizes the action of PG on sexual behavior in the female guinea pig.
先前的研究表明，金鱼排卵后不久，生殖系统合成的前列腺素（PG）会刺激雌性金鱼的产卵行为，且该前列腺素在大脑中发挥作用。在本研究中，可乐定以剂量依赖的方式抑制了未排卵雌性金鱼由PG诱导的产卵行为，同时也抑制了已排卵金鱼的产卵。在雄性金鱼中，可乐定同样抑制了PG诱导的雌性产卵行为，但不影响雄性的产卵行为。这些结果进一步支持了内源性PG在金鱼雌性产卵行为中的作用，并且与[15]的研究结果一致，即可乐定拮抗PG对雌性豚鼠性行为的作用。
