Stacey N E
Prostaglandins. 1976 Jul;12(1):113-26. doi: 10.1016/s0090-6980(76)80010-x.
In goldfish, injection of ovulated eggs (from donor females) through the ovipore and into the ovarian lumen of females with vitellogenic oocytes induces spawning behaviour within several hours. Intraperitoneal (i.p.) injection of indomethacin (IM), 10 mug/g, either 10 h prior to, or coincident with, injection of ovulated eggs, completely inhibits the onset of spawning behaviour. IM injection similarly terminates ongoing spawning behaviour induced by egg injection. PGF2alpha (5 mug/g; i.p. injection) restores spawning behaviour of egg-injected, IM-blocked fish; at the same dosage, PGE2 is marginally effective and PGE1 is without effect. As PGF2alpha and PGE2 also induce spawning behaviour in females which have not been injected with ovulated eggs, it is suggested that distension of the oviduct following ovulation or egg injection results in the release of PG which then acts in some way to induce spawning behaviour. The ability of PG to induce spawning behaviour is eliminated by hypophysectomy and restored by treatment with salmon gonadotropin: no steroid treatment was effective in restoring PG-induced spawning in fish which had been hypophysectomized for 3-4 months. The possible mode of action of PG in inducing spawning behaviour in female goldfish is discussed.
在金鱼中，将排卵的卵（来自供体雌鱼）通过排卵孔注入具有卵黄生成卵母细胞的雌鱼的卵巢腔，会在数小时内诱导产卵行为。在注入排卵的卵之前10小时或与之同时腹腔注射10微克/克消炎痛（IM），会完全抑制产卵行为的开始。IM注射同样会终止由卵注射诱导的正在进行的产卵行为。前列腺素F2α（5微克/克；腹腔注射）可恢复经卵注射、被IM阻断的鱼的产卵行为；在相同剂量下，前列腺素E2效果微弱，前列腺素E1则无效。由于前列腺素F2α和前列腺素E2也能在未注射排卵卵的雌鱼中诱导产卵行为，因此有人提出，排卵或卵注射后输卵管的扩张会导致前列腺素的释放，然后前列腺素以某种方式作用于诱导产卵行为。前列腺素诱导产卵行为的能力会因垂体切除而消除，并通过鲑鱼促性腺激素治疗得以恢复：对于已经垂体切除3 - 4个月的鱼，没有类固醇治疗能有效恢复前列腺素诱导的产卵。本文讨论了前列腺素在诱导雌性金鱼产卵行为中的可能作用方式。
