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双杠固定比率药物辨别任务中的最佳训练参数

Optimal training parameters in the two-bar fixed-ratio drug discrimination task.

作者信息

Overton D A, Hayes M W

出版信息

Pharmacol Biochem Behav. 1984 Jul;21(1):19-28. doi: 10.1016/0091-3057(84)90124-2.

DOI:10.1016/0091-3057(84)90124-2
PMID:6463088
Abstract

In a two-lever compartment, thirsty rats were trained to press one bar when drugged with phenobarbital and the other bar when undrugged using water as a reinforcer. Several different training procedures were employed in order to compare their effects on speed of acquisition and/or asymptotic accuracy of discrimination. Results were as follows: (1) Some shaping procedures allowed more rapid acquisition of discriminative control than others. The "traditional" shaping procedure was significantly less efficient than any others tested. (2) Several indices of degree of discriminability based on the speed of acquisition of discriminations were compared and evaluated. Some varied linearly with 1n dosage. (3) Variations in session duration from 5 to 60 minutes did not alter asymptotic accuracy. (4) Fixed ratio sizes ranging from FR-3 to FR-30 resulted in similar asymptotic accuracies. Overall, the results define alterations in the fixed-ratio training procedure that will make it somewhat easier to use. However, no procedures were found that fundamentally improved the properties of the paradigm.

摘要

在一个双杠杆实验箱中,口渴的大鼠接受训练,当用苯巴比妥麻醉时按压一根杠杆,未麻醉时按压另一根杠杆,以水作为强化物。采用了几种不同的训练程序,以便比较它们对习得速度和/或辨别渐近准确性的影响。结果如下:(1) 一些塑造程序比其他程序能使辨别控制的习得更快。“传统”塑造程序的效率明显低于所测试的任何其他程序。(2) 比较并评估了基于辨别习得速度的几种可辨别程度指标。有些指标与剂量的自然对数呈线性变化。(3) 实验时长从5分钟到60分钟的变化并未改变渐近准确性。(4) 固定比率大小从FR-3到FR-30产生了相似的渐近准确性。总体而言,结果确定了固定比率训练程序中的改变,这将使其使用起来稍微容易一些。然而,未发现能从根本上改善该范式特性的程序。

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