Cantor P, Rehfeld J F
Regul Pept. 1984 Apr;8(3):199-208. doi: 10.1016/0167-0115(84)90061-2.
Nerve terminals in pancreatic islets and ganglia containing cholecystokinin (CCK)/gastrin-like peptides are particularly abundant in the cat. In order to elucidate the possible origin and molecular nature of the peptides in these nerves, extracts of the feline pancreas, vagus, sympathetic trunk, and celiac-superior mesenteric ganglion were examined by gel chromatography monitored by sequence-specific radioimmunoassays. Small amounts of CCK-33 and CCK-8 were present in the pancreatic terminals. In the vagus and the sympathetic trunk, CCK, mainly as CCK-8, occurred in concentrations of 3.5 and 3.7 pmol/g. The celiac-superior mesenteric ganglion contained 40 pmol CCK/g distributed in five forms, including a predominant CCK-8-like component and a component eluting like CCK-4. Gastrins were not detected in the nervous structures. The results suggest that the celiac-superior mesenteric ganglia, the vagal nerves and the sympathetic trunks all may contribute to the CCK nerve terminals in the feline pancreas.
在猫体内，胰腺胰岛和含有胆囊收缩素（CCK）/胃泌素样肽的神经节中的神经末梢特别丰富。为了阐明这些神经中肽的可能来源和分子性质，通过序列特异性放射免疫测定监测的凝胶色谱法对猫胰腺、迷走神经、交感干和腹腔-肠系膜上神经节的提取物进行了检测。胰腺神经末梢中存在少量的CCK-33和CCK-8。在迷走神经和交感干中，CCK主要以CCK-8的形式存在，浓度分别为3.5和3.7 pmol/g。腹腔-肠系膜上神经节含有40 pmol CCK/g，以五种形式分布，包括一种主要的CCK-8样成分和一种洗脱行为类似CCK-4的成分。在神经结构中未检测到胃泌素。结果表明，腹腔-肠系膜上神经节、迷走神经和交感干都可能对猫胰腺中的CCK神经末梢有贡献。
