Hahn E F
Res Commun Chem Pathol Pharmacol. 1984 Jun;44(3):339-45.
Although a possible role for endogenous opioids in the regulation of feeding behavior has been proposed, little direct information is available concerning the impact of long term opiate antagonist treatment on body weight. Therefore, the effect of chronic exposure to naloxone on body weight was examined in WKY and SHR rats. Since the affinity of opiate antagonists for the receptor is increased by the presence of sodium ions, body weight was also determined in animals receiving a diet containing either 0.48% or 4% sodium chloride. Naloxone does not affect body weight in either strain of animals fed a normal (0.48% NaCl, Purina) diet. However, WKY rats fed the diet elevated in sodium chloride showed an increase in body weight which is blocked by treatment with naloxone. In contrast, SHR rats fed this diet weighed less than control animals receiving the normal diet, and naloxone did not decrease their weights further. These results suggest that naloxone may impact on mechanisms which regulate body weight, but is not capable of decreasing weight below a set point in either WKY or SHR rats.
尽管有人提出内源性阿片类物质在调节摄食行为中可能发挥作用，但关于长期使用阿片类拮抗剂治疗对体重的影响，目前几乎没有直接信息。因此，研究了在WKY和SHR大鼠中慢性暴露于纳洛酮对体重的影响。由于钠离子的存在会增加阿片类拮抗剂与受体的亲和力，因此还测定了食用含0.48%或4%氯化钠饮食的动物的体重。在喂食正常（0.48% NaCl，普瑞纳）饮食的两种品系动物中，纳洛酮均不影响体重。然而，喂食高氯化钠饮食的WKY大鼠体重增加，而纳洛酮治疗可阻止这种增加。相比之下，喂食这种饮食的SHR大鼠体重低于接受正常饮食的对照动物，且纳洛酮并未进一步降低它们的体重。这些结果表明，纳洛酮可能影响调节体重的机制，但在WKY或SHR大鼠中均无法使体重降至设定点以下。
