利巴韦林对细胞代谢的可逆性抑制作用。
Reversible inhibition of cellular metabolism by ribavirin.
作者信息
Larsson A, Stenberg K, Oberg B
出版信息
Antimicrob Agents Chemother. 1978 Feb;13(2):154-8. doi: 10.1128/AAC.13.2.154.
Abstract
The broad spectrum antiviral drug ribavirin (Virazole, 1-beta-d-ribofuranosyl-1,2,4-triazole-3-carboxamide) inhibits cellular macromolecular synthesis as well as cell division in eucaryotic cells. The concentration and time dependence have been studied. One-hour treatment with 25 muM ribavirin or 18 h with 2 muM inhibited the deoxyribonucleic acid synthesis to 50%. Higher concentrations of ribavirin were required to obtain a similar inhibition of ribonucleic acid and protein synthesis. This effect on cell metabolism and cell division can be reversed by removing the drug from the cells.
摘要
广谱抗病毒药物利巴韦林（病毒唑，1-β-D-呋喃核糖基-1,2,4-三唑-3-甲酰胺）可抑制真核细胞中的细胞大分子合成以及细胞分裂。已经对其浓度和时间依赖性进行了研究。用25μM利巴韦林处理1小时或用2μM处理18小时可将脱氧核糖核酸合成抑制至50%。需要更高浓度的利巴韦林才能对核糖核酸和蛋白质合成产生类似的抑制作用。通过从细胞中去除药物，这种对细胞代谢和细胞分裂的影响可以逆转。
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本文引用的文献
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Science. 1972 Aug 25;177(4050):705-6. doi: 10.1126/science.177.4050.705.
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Mechanism of action of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agent.新型广谱抗病毒药物1-β-D-呋喃核糖基-1,2,4-三唑-3-甲酰胺（病毒唑）的作用机制
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