Tarkowski A, Nilsson L A
Rheumatol Int. 1984;4(3):115-7. doi: 10.1007/BF00541179.
Serum levels of IgG, IgA and IgM rheumatoid factor (IgG RF, IgA RF and IgM RF) were determined by means of the diffusion-in-gel enzyme-linked immunosorbent assay (DIG-ELISA) in 42 Waaler-Rose negative patients with psoriatic arthropathy (PsA) type 1 (arthritis with involvement of distal interphalangeal joints) and type 3 (polyarthritis of rheumatoid type) according to the criteria of Moll and Wright as well as in 53 patients with Waaler-Rose negative rheumatoid arthritis (RA). Elevated levels of RF were found in 22% of patients with PsA type 3 and 45% of patients with Waaler-Rose negative RA. In contrast, none of the patients with PsA type 1 had detectable amounts of RF. It is suggested that the presence of IgG, IgA or IgM RF in patients having psoriasis in conjunction with inflammatory polyarthritis indicates the RA nature of the joint disease and should be considered as exclusion criterion for the diagnosis of PsA.
采用凝胶扩散酶联免疫吸附测定法（DIG-ELISA），根据莫尔（Moll）和赖特（Wright）的标准，对42例1型（累及远端指间关节的关节炎）和3型（类风湿性多关节炎）银屑病关节炎（PsA）的瓦勒-罗斯（Waaler-Rose）阴性患者以及53例瓦勒-罗斯阴性类风湿关节炎（RA）患者的血清IgG、IgA和IgM类风湿因子（IgG RF、IgA RF和IgM RF）水平进行了测定。在3型PsA患者中有22%以及瓦勒-罗斯阴性RA患者中有45%的患者类风湿因子水平升高。相比之下，1型PsA患者均未检测到可检测量的类风湿因子。提示银屑病合并炎性多关节炎患者中存在IgG、IgA或IgM类风湿因子表明关节疾病具有类风湿关节炎的性质，应被视为PsA诊断的排除标准。
