血小板增多症中的血小板乙二醛酶

Platelet glyoxalases in thrombocytosis.

作者信息

Leoncini G, Maresca M, Balestrero F, Armani U, Piana A

出版信息

Scand J Haematol. 1984 Jul;33(1):91-4. doi: 10.1111/j.1600-0609.1984.tb02216.x.

DOI:10.1111/j.1600-0609.1984.tb02216.x

Abstract

In platelets of patients suffering from thrombocytosis due to myeloproliferative disorders, glyoxalase I activity is significantly higher than in controls (P less than 0.01), while glyoxalase II levels are the same (P less than 0.3). The cellular concentration of glutathione is also increased in patients. Km values for methylglyoxal (glyoxalase I) and S-lactoylglutathione (glyoxalase II) are identical both in normal and pathological subjects, as are the thermostability of the two enzymes. The higher activity observed for glyoxalase I in patients could be related to a specific role of this enzyme in platelets.

摘要

在因骨髓增殖性疾病而患血小板增多症的患者的血小板中，乙二醛酶I的活性显著高于对照组（P小于0.01），而乙二醛酶II的水平相同（P小于0.3）。患者体内谷胱甘肽的细胞浓度也有所增加。正常人和病理受试者中甲基乙二醛（乙二醛酶I）和S-乳酰谷胱甘肽（乙二醛酶II）的Km值相同，两种酶的热稳定性也相同。在患者中观察到的乙二醛酶I的较高活性可能与其在血小板中的特定作用有关。