Høstmark J G, Laerum O D, Farsund T
Scand J Urol Nephrol. 1984;18(2):113-20. doi: 10.3109/00365598409182177.
DNA aberrations in bladder mucosa have been investigated in altogether 26 patients with aneuploid WHO grade 2 and 3 tumours (transitional cell carcinomas; TCC). In about 1/4 of the patients aneuploid cells were found only in the tumour. Hypotetraploid tumours showed the lowest frequency of involvement of the normal appearing mucosa of the trigone (43%). In hypertriploid tumours the corresponding value was 71%. In altogether 14 of the patients, the same type of aneuploid cells was found in the normal appearing mucosa as in the tumour. This indicates frequent involvement of the whole bladder mucosa in the tumour disease. In about 1/4 of the cases other types of ploidy aberrations were found in the normal appearing mucosa than in the tumour. This is indicative of preneoplastic changes in the mucosa, of which only one type of aberrations is associated with tumour growth. In some cases with multiple tumours of the bladder, all the tumours had the same aneuploid stemline, while in other cases the tumours were of different aneuploid stemlines. This is conformal with other reports of atypia in the surrounding mucosa in TCC and with the concept that recurrence of high grade tumours is the consequence of neoplastic involvement of the whole bladder.
对总共26例患有非整倍体WHO 2级和3级肿瘤（移行细胞癌；TCC）的患者的膀胱黏膜中的DNA畸变进行了研究。约四分之一的患者仅在肿瘤中发现非整倍体细胞。亚四倍体肿瘤中三角区外观正常的黏膜受累频率最低（43%）。在超三倍体肿瘤中，相应的值为71%。总共14例患者在外观正常的黏膜中发现与肿瘤中相同类型的非整倍体细胞。这表明肿瘤疾病中整个膀胱黏膜经常受累。约四分之一的病例中，在外观正常的黏膜中发现的倍体畸变类型与肿瘤中的不同。这表明黏膜存在癌前变化，其中只有一种畸变类型与肿瘤生长相关。在一些膀胱多发肿瘤的病例中，所有肿瘤具有相同的非整倍体主干系，而在其他病例中，肿瘤具有不同的非整倍体主干系。这与其他关于TCC周围黏膜异型性的报道以及高级别肿瘤复发是整个膀胱肿瘤累及结果的概念相符。
