Gormley D E, Hirsch P
Arch Dermatol. 1978 May;114(5):782-3.
Three examples of an unusually aggressive form of basal cell carcinoma in the skin of the scalp were treated surgically. The extent of each tumor was verified with gross and microscopic examination. The tumors invaded fat, muscle, fascia, and bone. Dural involvement was seen in one case. Light microscopy showed a marked variation in growth patterns and cytologic types from one portion of the tumor to another. Characteristics included a diffusely infiltrating pattern with a fibrotic stromal response, rare intraepidermal tumor nests, formation of occasional duct-like structures, poor cellular cohesion with single-life invasion through dermal collagen, perineural invasion, and pleomorphism with varying nuclear cytoplasmic ratios. Basaloid populations with peripheral palisading were seen in each tumor. These malignancies may be representative of an unusual basal cell carcinoma variant unique to the scalp.
对头皮皮肤中出现的三例异常侵袭性基底细胞癌进行了手术治疗。通过大体和显微镜检查确定了每个肿瘤的范围。肿瘤侵犯了脂肪、肌肉、筋膜和骨骼。其中一例可见硬脑膜受累。光镜检查显示，肿瘤不同部位的生长模式和细胞类型存在显著差异。其特征包括弥漫性浸润模式伴纤维化间质反应、罕见的表皮内肿瘤巢、偶尔形成导管样结构、细胞黏附性差伴单个细胞穿过真皮胶原侵袭、神经周围侵袭以及核质比不同的多形性。每个肿瘤中均可见具有周边栅栏状排列的基底样细胞群。这些恶性肿瘤可能代表了一种头皮特有的异常基底细胞癌变体。
