镉对虹鳟（Salmo gairdneri）睾丸类固醇生成的影响。

The effect of cadmium on steroidogenesis by testes of the rainbow trout, Salmo gairdneri.

作者信息

Kime D E

出版信息

Toxicol Lett. 1984 Jul;22(1):83-8. doi: 10.1016/0378-4274(84)90049-3.

Abstract

Testes of the rainbow trout were incubated in the presence of 0, 0.05, 0.5 and 5 mM cadmium (Cd). Production of those steroids measured was stimulated by 0.05 and 0.5 mM cadmium. Yields of testosterone (T) and 11 beta-hydroxytestosterone (beta) were significantly increased at these concentrations, but there was little effect on glucuronyl transferase and 11 beta-hydroxysteroid dehydrogenase enzyme activities. Cd-induced alteration of the hormonal balance may result in perturbation of reproductive development.

摘要

虹鳟鱼的睾丸在含有0、0.05、0.5和5 mM镉（Cd）的条件下进行孵育。所检测的那些类固醇的产生受到0.05和0.5 mM镉的刺激。在这些浓度下，睾酮（T）和11β-羟基睾酮（β）的产量显著增加，但对葡萄糖醛酸转移酶和11β-羟基类固醇脱氢酶的活性影响很小。镉诱导的激素平衡改变可能导致生殖发育紊乱。