Pitkänen M A, Hietanen T
Strahlentherapie. 1984 Jun;160(6):394-7.
The extraction of 86Rb chloride, the red blood cell volume and the mineral content in the rat femur have been studied 7 months after local X-irradiation. Doses were given as 3, 6 and 9 fractions over three weeks. The total doses used were based on NSD value of 1450 and 1900 on the basis of the results from our previous single dose irradiation studies. The reduction in the extraction of 86Rb chloride was statistically significant for all fractionation schemes and at both NSD levels. In the whole femur, with bone marrow, the extraction was reduced by 33% to 46%. In the hard bone the reduction was less only 18% to 38%. There was no significant difference between the fractionation schemes used at each NSD level. The red blood cell volume was significantly reduced in the whole femur, with bone marrow, with no difference between the fractionation schemes. However, there was no change in the hard bone. The dry bone weight was reduced by 3 to 6% with no significant difference between the different fractionation schemes. The dose levels predicted by the NSD formula produced approximately the same damage to the rat femur 7 months after the irradiation when the dry weight and the extraction of 86Rb chloride were used as end points for the evaluation of the severity of late radiation damage.
在局部X线照射7个月后，对大鼠股骨中氯化铷的提取、红细胞体积和矿物质含量进行了研究。剂量在三周内分3、6和9次给予。根据我们之前单次剂量照射研究的结果，所使用的总剂量基于1450和1900的NSD值。对于所有分割方案和两个NSD水平，氯化铷提取量的降低均具有统计学意义。在包含骨髓的整个股骨中，提取量降低了33%至46%。在硬骨中，降低幅度较小，仅为18%至38%。在每个NSD水平使用的分割方案之间没有显著差异。在包含骨髓的整个股骨中，红细胞体积显著降低，分割方案之间没有差异。然而，硬骨中没有变化。干骨重量降低了3%至6%，不同分割方案之间没有显著差异。当使用干重和氯化铷提取量作为评估晚期放射损伤严重程度的终点时，NSD公式预测的剂量水平在照射7个月后对大鼠股骨产生了大致相同的损伤。
