Pitkänen M A, Hopewell J W
Strahlentherapie. 1985 Nov;161(11):719-23.
Time and dose dependent changes in blood flow and red blood cell volume were studied in the locally irradiated bone marrow of the rat femur after single and fractionated doses of X-rays. With the single dose of 10 Gy the bone marrow blood flow although initially reduced returned to the control levels by seven months after irradiation. With doses greater than or equal to 15 Gy the blood flow was still significantly reduced at seven months. The total dose levels predicted by the nominal standard dose equation for treatments in three, six or nine fractions produced approximately the same degree of reduction in the bone marrow blood flow seven months after the irradiation. However, the fall in the red blood cell volume was from 23 to 37% greater in the three fractions groups compared with that in the nine fractions groups. Using the red blood cell volume as a parameter the nominal standard dose formula underestimated the severity of radiation damage in rat bone marrow at seven months for irradiation with small numbers of large dose fractions.
在对大鼠股骨局部照射的骨髓中，研究了单次及分次X射线照射后血流和红细胞体积随时间和剂量的变化。单次给予10 Gy剂量时，骨髓血流虽最初减少，但照射后7个月恢复至对照水平。剂量大于或等于15 Gy时，7个月时血流仍显著减少。对于分3次、6次或9次照射治疗，由标称标准剂量方程预测的总剂量水平在照射后7个月产生的骨髓血流减少程度大致相同。然而，与9分次组相比，3分次组的红细胞体积下降幅度要大23%至37%。以红细胞体积作为参数，对于少量大剂量分次照射，标称标准剂量公式在7个月时低估了大鼠骨髓辐射损伤的严重程度。
