对呼吸窘迫婴儿进行氧含量曲线的系列测定。
Serial determinations of oxygen profiles in infants with respiratory distress.
作者信息
Holman W L, Krauss A N, Auld P A
出版信息
Arch Dis Child. 1978 Feb;53(2):136-40. doi: 10.1136/adc.53.2.136.
Serial oxygen profiles were determined for 20 newborn infants by measuring arterial tensions at low (20--40%), intermediate (60--80%), and high (95--100%) levels of inspired oxygen. These points were plotted on a graph which estimated the percentage of venous admixture at any particular level of inspired oxygen. The infants' oxygen profiles were then determined. As much as 25% of venous admixture could be attributed to the presence of diffusion and distribution abnormalities in infants with hyaline membrane disease. A substantial number of infants showed increased shunting at high levels of oxygen, even in the presence of continuous distending airway pressure. It is hypothesised that a rising shunt is due to complete absorption of gas in poorly ventilated alveoli at high concentrations of inspired oxygen, resulting in the presence of atelectasis and redistribution of blood to poorly ventilated areas.
通过测量20名新生儿在低（20%-40%）、中（60%-80%）、高（95%-100%）吸入氧水平下的动脉血氧张力，测定了连续的氧分压曲线。将这些点绘制在一张图表上，该图表可估算在任何特定吸入氧水平下静脉血掺杂的百分比。然后确定了婴儿的氧分压曲线。在患有透明膜病的婴儿中，高达25%的静脉血掺杂可归因于存在弥散和分布异常。相当多的婴儿即使在持续气道扩张压存在的情况下，在高氧水平时也显示分流增加。据推测，分流增加是由于在高浓度吸入氧时，通气不良的肺泡中气体完全吸收，导致肺不张的出现以及血液重新分布到通气不良区域。
Zotero 插件