凯尔（K1）抗原表达减弱的罕见例子。

A rare example of weakened expression of the Kell (K1) antigen.

作者信息

Kline W E, Sullivan C M, Bowman R J

出版信息

Vox Sang. 1984;47(2):170-3. doi: 10.1111/j.1423-0410.1984.tb01579.x.

DOI:10.1111/j.1423-0410.1984.tb01579.x

Abstract

Random typing of donor units revealed a donor whose red blood cells gave very weak reactions with all anti-Kell (anti-K1) antisera. All other Kell-system antigen was present in four generations of the donor's family. The red-cell morphology is normal in all family members with the weakened K1 antigen. A consistent hypothesis is that the weak antigen is inherited through a variant allele at the Kell locus and represents a quantitative, not a qualitative, change.

摘要

对供血者单位进行随机分型时，发现一名供血者的红细胞与所有抗凯尔（抗-K1）抗血清反应非常微弱。该供血者家族的四代成员中均存在所有其他凯尔系统抗原。K1抗原减弱的所有家族成员的红细胞形态均正常。一个一致的假设是，这种弱抗原是通过凯尔基因座上的一个变异等位基因遗传而来的，代表的是一种数量上而非质量上的变化。