Teare F W, Read P R, Pyttel R B, Jasansky P A
Arch Environ Health. 1978 Mar-Apr;33(2):53-8. doi: 10.1080/00039896.1978.10667309.
Intracellular hepatic distribution of cadmium in male Wistar rats were determined after various time intervals up to 6 months following a single intraperitoneal injection of cadmium chloride (3.75 mg/kg). After an initial liver accumulation period of approximately 2 weeks, cadmium was slowly eliminated. This decrease occurred primarily in the soluble fraction, but also to a lesser extent in the nuclear and mitochondrial fractions. No detectable decrease of cadmium was observed in the microsomal fraction. There was no apparent redistribution of cadmium within these hepatic fractions during the 6-month period of study. A comparison of the intracellular cadmium distribution following administration by intraperitoneal, oral, and pulmonary routes revealed that in each instance the soluble fraction contained the greatest amount of this element by far with decreasing amounts in the microsomes, mitochondria, and nuclei in that order.
在雄性Wistar大鼠单次腹腔注射氯化镉（3.75毫克/千克）后，测定长达6个月的不同时间间隔内镉在肝脏细胞内的分布情况。在最初约2周的肝脏蓄积期后，镉被缓慢清除。这种减少主要发生在可溶性部分，但在核部分和线粒体部分也有较小程度的减少。微粒体部分未观察到镉的可检测减少。在6个月的研究期间，这些肝脏部分内未观察到镉的明显重新分布。通过腹腔、口服和肺部途径给药后细胞内镉分布的比较显示，在每种情况下，可溶性部分所含该元素的量迄今为止最大，微粒体、线粒体和细胞核中的量依次减少。
