Tandon S K, Asokan P
Acta Pharmacol Toxicol (Copenh). 1981 Nov;49(5):381-3. doi: 10.1111/j.1600-0773.1981.tb00919.x.
Cadmium chloride cleared rapidly from the lungs and translocated mainly into the liver within 24 hrs of an intratracheal instillation. Further pulmonary clearance and hepatic accumulation were very slow during the remaining observation period of 24 days. Though, the uptake of cadmium by kidneys was lower but the level increased consistently with the time after instillation. The induction of metallothionein synthesis by cadmium might be responsible for accumulation and retention of cadmium in liver and kidneys significantly.
气管内注入氯化镉后24小时内，其迅速从肺部清除，主要转移至肝脏。在随后24天的观察期内，肺部的进一步清除及肝脏的蓄积非常缓慢。虽然肾脏对镉的摄取较低，但注入后其水平随时间持续升高。镉诱导金属硫蛋白合成可能是导致镉在肝脏和肾脏中显著蓄积和潴留的原因。
