Amland P F, Jorde R, Giercksky K E, Kildebo S, Burhol P G
Acta Chir Scand. 1984;150(3):223-8.
23 obese and 17 control subjects were studied after ingestion of a heavy breakfast, and 11 obese and 11 control subjects were studied after ingestion of a mixed liquid test meal. Five subjects from the latter group were also studied two and six weeks after a jejuno-ileal bypass operation and the remaining six subjects from this group were studied twelve weeks after a stapled gastric partitioning. No significant differences in fasting or postprandial serum gastrin levels were found between the obese and the lean subjects, neither when studied with the breakfast meal nor when studied with the mixed liquid test meal. After the jejuno-ileal bypass operation the serum gastrin levels were not significantly different from the preoperative ones, whereas both the fasting and the postprandial serum gastrin levels were significantly augmented after the stapled gastric partitioning procedure. The group operated on with the latter method was also studied with an insulin test before and after the operation. Similar to that seen after ingestion of the mixed liquid test meal, the serum gastrin levels after the insulin-induced hypoglycemia were significantly higher postoperatively.
对23名肥胖受试者和17名对照受试者在摄入丰盛早餐后进行了研究，对11名肥胖受试者和11名对照受试者在摄入混合液体试验餐后进行了研究。后一组中的5名受试者在空肠回肠旁路手术后2周和6周也进行了研究，该组其余6名受试者在胃吻合术后12周进行了研究。肥胖受试者和瘦受试者之间，无论是在摄入早餐餐时还是在摄入混合液体试验餐时，空腹或餐后血清胃泌素水平均未发现显著差异。空肠回肠旁路手术后血清胃泌素水平与术前无显著差异，而在胃吻合术后，空腹和餐后血清胃泌素水平均显著升高。对采用后一种方法进行手术的组在手术前后也进行了胰岛素试验研究。与摄入混合液体试验餐后的情况相似，胰岛素诱导低血糖后血清胃泌素水平术后显著升高。
