Hans P, Born J D, Chapelle J P, Spyropoulos E, Bodson L
Acta Anaesthesiol Belg. 1984 Mar;35(1):79-86.
We studied CSF CK and LDH isoenzyme activities in 27 patients with severe head injury and in 10 patients with chronic hydrocephalus not related to trauma. CSF enzymes showed an increased activity immediately after trauma, contrasting with the low values measured in the patients with hydrocephalus. In severe head injury, we found a correlation between enzyme release and brain dysfunction assessed according to two methods: the Glasgow coma scale (GCS), and the Liège coma scale (LCS) which uses elements of the GCS and the study of 5 brain stem reflexes. The correlation between enzyme activity and the Liège coma scores is better than that observed with the Glasgow coma scores. High enzyme activity is associated with a bad outcome at six months. It has a prognostic value on so far as it reflects the severity of traumatic structural brain damage.
我们研究了27例重型颅脑损伤患者和10例与创伤无关的慢性脑积水患者脑脊液中肌酸激酶（CK）和乳酸脱氢酶（LDH）同工酶的活性。创伤后立即发现脑脊液酶活性增加，这与脑积水患者测得的低值形成对比。在重型颅脑损伤中，我们发现根据两种方法评估的酶释放与脑功能障碍之间存在相关性：格拉斯哥昏迷量表（GCS）和使用GCS要素及5种脑干反射研究的列日昏迷量表（LCS）。酶活性与列日昏迷评分之间的相关性优于与格拉斯哥昏迷评分之间的相关性。高酶活性与6个月时的不良预后相关。就其反映创伤性脑结构损伤的严重程度而言，它具有预后价值。
