Kawamoto K, Kawashima S
Acta Anat (Basel). 1984;119(3):136-41. doi: 10.1159/000145875.
Ultrastructural changes and proliferation of pituicytes during water deprivation and rehydration were studied in the posterior lobe of C57BL/Tw mice. Deprivation for 3 days brought about a significant increase in the number of electron-dense bodies (lysosomes) in pituicyte perikarya and their processes. The frequency of pituicytes enclosing neurosecretory axons in their cytoplasm significantly decreased as compared with that of the controls. 12-hour rehydration following deprivation for 3 days induced extensive development of rough endoplasmic reticulum and Golgi apparatus and an increase in frequency of neurosecretory axons enwrapped by pituicyte cytoplasm. However, at 2 days of rehydration the morphology of pituicytes was no more different from that of the controls. Mitotic figures of pituicytes were not encountered throughout the deprivation period of 6 days, but rehydration for 12 h and 1, 2, or 3 days following deprivation for 3 or 6 days was effective in eliciting an increase in mitotic activity. The present results indicate that pituicytes in the mouse posterior lobe are intimately related with the secretory mechanism of neurosecretory material from the neurosecretory axons and that the proliferation of pituicytes is stimulated in conditions of reaccumulation of neurosecretory material.
研究了C57BL/Tw小鼠后叶在缺水和再水化过程中垂体细胞的超微结构变化和增殖情况。缺水3天导致垂体细胞胞体及其突起中电子致密体（溶酶体）数量显著增加。与对照组相比，细胞质中包裹神经分泌轴突的垂体细胞频率显著降低。缺水3天后进行12小时再水化，诱导粗面内质网和高尔基体广泛发育，且被垂体细胞质包裹的神经分泌轴突频率增加。然而，再水化2天时，垂体细胞的形态与对照组不再有差异。在6天的缺水期内未观察到垂体细胞的有丝分裂象，但在缺水3天或6天后进行12小时以及1、2或3天的再水化，可有效促使有丝分裂活性增加。目前的结果表明，小鼠后叶的垂体细胞与神经分泌轴突中神经分泌物质的分泌机制密切相关，并且在神经分泌物质重新积累的情况下，垂体细胞的增殖受到刺激。
